Abstract Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study. Results: There were no significant difference between groups (p>0.05). In the soft dermis there was more type I collagen production in group I (p<0.05), group II and III was similar re-sults (p>0.05). In the compact dermis, all 3 groups showed similar results (p>0.05). The biomechanical study was similarity between the glue groups (p>0.05) but the group III proved to be different from the others having a higher resistance (p>0.05) . Conclusion: This glue does not cause any inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the glue should be used alone only in less tension are-as.

Abstract Acute renal failure (ARF) is an extremely important public health issue in need of novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem cell (MSC) therapy to promote the improvement and recovery of renal function in a preclinical model. Wistar rats were used as the experimental model, and our results show that cisplatin (5mg/kg) can efficiently induce ARF, as measured by changes in biochemical (urea and creatinine) and histological parameters. MSC therapy performed 24h after the administration of chemotherapy resulted in normalized plasma urea and creatinine levels 30 and 45d after the onset of kidney disease. Furthermore, MSC therapy significantly reduced histological changes (intratubular cast formation in protein overload nephropathy and tubular hydropic degeneration) in this ARF model. Thus, considering that current therapies for ARF are merely palliative and that MSC therapy can promote the improvement and recovery of renal function in this model system, we suggest that innovative/alternative therapies involving MSCs should be considered for clinical studies in humans to treat ARF.

OBJETIVO: Estudar a obesidade grau III ou grave, identificando o perfil demográfico, clínico e as doenças de maior ocorrência, em pacientes atendidos na consulta de enfermagem, candidatos a cirurgia bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul. MÉTODOS: Trata-se de um estudo descritivo, com análise dos registros em 252 prontuários dos pacientes atendidos no Programa de Cirurgia Bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, entre 2004 a 2007. RESULTADOS: A prevalência crescente de sobrepeso e obesidade está associada a doenças crônicas relacionadas à dieta (comorbidades). Dos 252 pacientes atendidos 80,15% eram do sexo feminino; a média da idade foi de 36,07±10,16 anos; quanto à etnia 86,53% eram brancos, 8,57% pardos e 4,90% negros; houve predomínio das comorbidades: hipertensão arterial (63,49%), dispnéia (55,56%), varizes de membros inferiores (45,63%) e depressão (36,51%). CONCLUSÃO: observa-se que a doença de maior ocorrência na obesidade é a hipertensão arterial, devendo o paciente ser acompanhado por uma equipe multidisciplinar.

OBJECTIVE: To identify the demographic and clinical profile of individuals with severe obesity who were candidates for bariatric surgery. METHODS: This was a descriptive study. Data were extracted from 252 medical records of candidates for bariatric surgery in the Hospital of the Federal University of Mato Grosso do Sul from 2004 through 2007. RESULTS: The prevalence of obesity was associated with other chronic diseases related to the eating habits. The majority of candidates for bariatric surgery were whites (86.53%) and female (80.15%). The mean age of the candidates was 36.07±10.16 years. The most common commorbidities included high blood pressure (63.49%), dyspnea (55.56%), varicose veins (45.63%), and depression (36.51%). CONCLUSION: The major comorbidity associated with obesity is high blood pressure; individuals need be followed by a multidisciplinary team of health care providers.

OBJETIVO: Estudiar la obesidad con grado III o grave, identificando el perfil demográfico, clínico y la enfermedades de mayor ocurrencia, en pacientes atendidos en la consulta de enfermería, candidatos a cirugía bariátrica del Núcleo del Hospital Universitario (NHU) de la Universidad Federal de Mato Grosso do Sul (UFMS). MÉTODOS: Se trata de un estudio descriptivo, con análisis de los registros en historias clínicas de los pacientes atendidos en el Programa de Cirugía Bariátrica del Núcleo del Hospital Universitario de la Universidad Federal de Mato Grosso do Sul, entre el 2004 al 2007. RESULTADOS: La prevalencia creciente de exceso de peso y obesidad está asociada a enfermedades crónicas relacionadas a la dieta (comorbidades). De los 252 pacientes atendidos el 80,15% eran del sexo femenino y el 19,84% del masculino; el promedio de edad fue de 36,07±10,16 años; en cuanto a la etnia el 86,53% eran blancos, el 8,57% pardos y el 4,90% negros; hubo predominio de las comorbidades: hipertensión arterial (63,49%), disnea (55,56%), várices de miembros inferiores (45,63%) y depresión (36,51%). CONCLUSIÓN: Se observa que la enfermedad de mayor ocurrencia en la obesidad es la hipertensión arterial, siendo necesario que el paciente sea acompañado por un equipo multidisciplinario.

OBJECTIVE: To identify the demographic and clinical profile of individuals with severe obesity who were candidates for bariatric surgery. METHODS: This was a descriptive study. Data were extracted from 252 medical records of candidates for bariatric surgery in the Hospital of the Federal University of Mato Grosso do Sul from 2004 through 2007. RESULTS: The prevalence of obesity was associated with other chronic diseases related to the eating habits. The majority of candidates for bariatric surgery were whites (86.53%) and female (80.15%). The mean age of the candidates was 36.07±10.16 years. The most common commorbidities included high blood pressure (63.49%), dyspnea (55.56%), varicose veins (45.63%), and depression (36.51%). CONCLUSION: The major comorbidity associated with obesity is high blood pressure; individuals need be followed by a multidisciplinary team of health care providers.

OBJETIVO: Estudiar la obesidad con grado III o grave, identificando el perfil demográfico, clínico y la enfermedades de mayor ocurrencia, en pacientes atendidos en la consulta de enfermería, candidatos a cirugía bariátrica del Núcleo del Hospital Universitario (NHU) de la Universidad Federal de Mato Grosso do Sul (UFMS). MÉTODOS: Se trata de un estudio descriptivo, con análisis de los registros en historias clínicas de los pacientes atendidos en el Programa de Cirugía Bariátrica del Núcleo del Hospital Universitario de la Universidad Federal de Mato Grosso do Sul, entre el 2004 al 2007. RESULTADOS: La prevalencia creciente de exceso de peso y obesidad está asociada a enfermedades crónicas relacionadas a la dieta (comorbidades). De los 252 pacientes atendidos el 80,15% eran del sexo femenino y el 19,84% del masculino; el promedio de edad fue de 36,07±10,16 años; en cuanto a la etnia el 86,53% eran blancos, el 8,57% pardos y el 4,90% negros; hubo predominio de las comorbidades: hipertensión arterial (63,49%), disnea (55,56%), várices de miembros inferiores (45,63%) y depresión (36,51%). CONCLUSIÓN: Se observa que la enfermedad de mayor ocurrencia en la obesidad es la hipertensión arterial, siendo necesario que el paciente sea acompañado por un equipo multidisciplinario.

OBJETIVO: Estudar a obesidade grau III ou grave, identificando o perfil demográfico, clínico e as doenças de maior ocorrência, em pacientes atendidos na consulta de enfermagem, candidatos a cirurgia bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul. MÉTODOS: Trata-se de um estudo descritivo, com análise dos registros em 252 prontuários dos pacientes atendidos no Programa de Cirurgia Bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, entre 2004 a 2007. RESULTADOS: A prevalência crescente de sobrepeso e obesidade está associada a doenças crônicas relacionadas à dieta (comorbidades). Dos 252 pacientes atendidos 80,15% eram do sexo feminino; a média da idade foi de 36,07±10,16 anos; quanto à etnia 86,53% eram brancos, 8,57% pardos e 4,90% negros; houve predomínio das comorbidades: hipertensão arterial (63,49%), dispnéia (55,56%), varizes de membros inferiores (45,63%) e depressão (36,51%). CONCLUSÃO: observa-se que a doença de maior ocorrência na obesidade é a hipertensão arterial, devendo o paciente ser acompanhado por uma equipe multidisciplinar.

OBJETIVO: estabelecer comparação entre as propriedades mecânicas das tenorrafias realizadas com poliamida (náilon) e polidioxanona (PDS). MÉTODOS: Foram utilizados 56 coelhos adultos, machos, Nova Zelândia, distribuídos em dois grupos e quatro subgrupos: GIA - tenorrafias com polidioxanona e avaliação após duas semanas; GIB - tenorrafias com polidioxanona e avaliação após quatro semanas; GIIA - tenorrafias com náilon e avaliação após duas semanas; GIIB - tenorrafias com náilon e avaliação após quatro semanas. Foram realizados ensaios de tração nas tenorrafias dos tendões dos coelhos. RESULTADOS: na avaliação aos quinze dias de pós-operatório, o náilon apresentou como resultados dos ensaios mecânicos, valores superiores que os do PDS para carga máxima, coeficiente de rigidez, deformação, deformação no limite de proporcionalidade, carga no limite de proporcionalidade, que foram as variáveis analisadas. CONCLUSÃO: aos trinta dias de pós-operatório não houve diferença significante entre o uso do náilon e o PDS.

OBJECTIVE: comparative study between the mechanical properties of the tenorraphies with poliamida (nylon) and polidioxanone (PDS). METHODS: 56 adult, male, New Zealand rabbits were used, distributed in two groups and four sub groups: GIA-tenorraphies with polidioxanone and evaluation after two weeks; GIB-tenorraphies with polidioxanone and evaluation after four weeks; GIIA-tenorraphies with nylon and evaluation after two weeks; GIIB-tenorraphies with nylon and evaluation after four weeks. Traction tests were done in tenorraphies of the rabbits. RESULTS: after fifteen days nylon presented as results of the mechanical tests, superior values that the one of PDS for maximum load, rigidity coefficient, deformation, deformation in the proportionality limit, load in the proportionality limit, that were the variable analysed. CONCLUSION: after thirty days there was not significant difference between nylon and PDS.